Today vs. three years ago (in parenthesis): Lastpass (Roboform), Firefox/Chrome (Firefox).
Same as before but newer versions: Office, Trillian, Fireworks, WinSCP, Ultraedit, VLC.
New: Droplr, Filezilla (mac), Textwrangler (mac)
Don't use anymore: SecureCRT, Popfile
Web-based: Gmail, Google Calendar + Chartbeat, Backpack
Other apps for specific uses: uTorrent/Transmission, Notepad, Frontpage, IE, OpenVPN, WinMerge.
All in all, the apps I use daily have changed very little.
Copernic Dektop Search
K-Lite Mega Codec Pack with Media Player Classic
... and that's all
I like to keep my programs to a minimum, although I am not sure if this benefits or hiders me more.
*Java (32 and 64 bit and 64 bit JDK)
*eclipse (for Java programming)
*PDF X-Change (fast, has a firefox plugin)
*open office (saved me 100 bucks)
*PSPad Editor (got it a while ago for hexadecimal editing and have never switched over to something more feature rich like notepad++)
*gimp (so many features once you figure out how to use them)
*VLC media player (when windows media player can't open a file, I like how it does not have to install, you just unzip the download folder and place it where ever you want)
Auslogics Disk Defrag
Browsers (Depends on type of computer and user but Firefox for me)
If XP then Taskbar Shuffle is a must
Microsoft Security Essentials
VLC Player or K-Lite Codecs For WinMPlayer
Foxit or Sumatra PDF Reader
Sophos Anti Virus
iZip or Keka
Burn Or SimplyBurns
Windows Update for 1 hour =P
First security: MSE, Spybot S&D, Adaware
Internet: Chrome and Firefox
Then stuff to install other stuff: 7-zip, Quickpar, Daemon Tools
Media: VLC, Media Player Classic
The rest: Newsbin Pro, Skype, Adobe Reader, CC Cleaner, CPUID, CoreTemp, LibreOffice, MixMeister, Steam, CD Burner XP