Unless you have some crazy resolution I'm gonna say you will be more than fine . Hopefully it'll be properly supported out of the box; this is a major release though so I'd imagine any issues would be addressed very quickly.
Of course it will run it, even with a single GPU. 60fps ,,, 1080p 8xAA 16xAF I have a friend with your similar config without Xfire and he runs skyrim and it flys. no slow downs. You have crossfire which will make sure your framerate never drops below 60fps or 50fps.. thx gl