Although you'll be hard pressed to find better prices than previously offered by the Humble Indie Bundle, Steam and its fellow distributors are serving up to 75% off popular indie titles, including Super Meat Boy, Braid, VVVVVV, Machinarium and World of Goo. There aren't many individual AAA discounts this week, but Impulse offers a hefty 2K Games pack with BioShock, Borderlands, Duke Nukem Forever, Mafia III, as well as a ton of Sid Meier's and X-COM titles for only $69.99.

Steam
85 Super Meat Boy Anniversary Pack $24.99 (75% off)
88 Sins of a Solar Empire: Trinity $14.99 (25% off)
75 Magicka Collection $6.24 (75% off)
82 Bejeweled 3 $9.99 (50% off)
90 World of Goo $4.99 (50% off)
Aquaria $4.99 (50% off)
88 Braid $4.99 (50% off)
86 Machinarium $4.99 (50% off)
Bit.Trip Runner $4.99 (50% off)
Bit.Trip Beat $4.99 (50% off) 
82 Rush $2.49 (50% off)
83 VVVVVV $2.49 (50% off)
Gish $4.99 (50% off)
More...

Impulse
81 Tropico Trilogy $9.99 (50% off)
Europa Universalis III Chronicles $8.99 (70% off)
84 Rift $9.99 (67% off) 
 Dawn of Fantasy $14.99 (50% off)
Neverwinter Nights Diamond $4.99 (50% off)
2K Ultimate Bundle $69.99 (78% off)
Final Fantasy XI Ultimate Collection $9.99 (50% off)
A Valley Without Wind $9.99 (50% off)
More...

GamersGate
82 Just Cause 2 $4.99 (75% off)
85 Jamestown: Legend of the Lost Colony $4.98 (50% off)
89 Bastion $7.50 (50% off)
86 Frozen Synapse $7.98 (60% off)
Really Big Sky $4.00 (50% off)
81 Solar 2 $4.98 (50% off)
77 Zeno Clash $5.98 (60% off)
Just Cause $3.75 (75% off)
More...

Origin
80 FIFA Soccer 10 $4.99 (50% off)
85  FIFA Soccer 11 $9.99 (75% off)
80 Need for Speed Shift $9.99 (50% off)
86 Battlefield: Bad Company 2 $9.99 (50% off)
93 Mass Effect 2: Deluxe Edition $9.99 (66% off)
Need for Speed ProStreet $4.99 (50% off)
More...

Direct2Drive
42  Ship Simulator Extremes $10.50 (65% off)
Call of Duty Warchest $19.95 (50% off)
More...

Good Old Games
60% off the 1C Catalog