Bryan Johnson, the millionaire biohacker who wants to live forever, diagnosed with incurable autoimmune disease

[Theinsanegamer]

You don't need to misuse terms to explain the ubiquitous desire of humans to live longer. Rapamycin dramatically extends the lifespan of mice and some other animals, and it's been deemed FDA-safe for human consumption for decades: what's so strange about him testing that upon himself? Early cancer researchers intentionally injected themselves with cancer cells and even sewed live tumors from other patients into their own body. Compared to that, this n-of-one study is hardly extreme.

And you don't have act like a prick, but here we are.

I didn't misuse any term. Doing this much to your body attempting to STOP AGING, something that is impossible, is not normal behavior.

Taking 54 supplements a day is not normal.

Taking immune suppressants when you don't need them is not normal.

Injecting your son's plasma is not normal.

And just because a medicine is "safe to use" in humans does NOT mean such medicine has no side effects or negative outcomes.

"While preclinical data supports its potential for healthspan extension, clinical evidence in healthy adults remains limited, and unsupervised use carries significant health risks.

What emerges is a complex picture that remains insufficient to affirm or negate the longevity and healthspan extending benefits attributed to rapamycin."

https://www.aging-us.com/news-room/...ence-for-longevity-benefits-in-healthy-adults

Turns out, like most supplements, there is no actual concrete evidence for their claims. May as well listen to Liver King and eat raw beef testicles every day.

This is scientific cargo cult behavior. We have a term for constantly believing your body is insufficient in some way and having a strong conviction to change it, often with severe treatment and long term derogatory effects: dysmorphia.

 

[BumFarto]

I think the other issue here is that he’s not truly rich enough to fund serious research into anti aging. There are billionaires who have and massive pharmaceutical companies who are also researching this. What’s interesting is that there has been relatively little progress - at best it’s been incremental reduction in “environmental” or lifestyle harms.

It suggests to me that nature has “coded” in dna a strong life limiter presumably as a result of evolutionary factors. Some animals/organisms have extremely long life spans and some incredibly short. Again, this would seem to imply the issue isn’t aging as a disease or aging because of damage/harms in the environment or life led but rather a genetic limiter.

That’s why his methods to extend life are doomed to fail, imo.

 

[Endymio]

And you don't have act like a prick, but here we are.

I didn't misuse any term. Doing this much to your body attempting to STOP AGING, something that is impossible, is not normal behavior.

You certainly did misuse the term. His expectations may be unrealistic, even wildly so -- but they're based on a normal, commonplace motivation, and not a pathological belief his own health is somehow compromised.

Taking 54 supplements a day is not normal.
Taking immune suppressants when you don't need them is not normal.

Is sewing a live cancer tumor into your body normal? Is intentionally infecting your digestive tract with dangerous bacteria normal? Is injecting the pus from a swollen bartenellosis boil normal? This is how medical knowledge is advanced.

Turns out, like most supplements, there is no actual concrete evidence for their claims.

Why not read your own links?

" The findings point to the urgent need for larger, better-designed human trials...."

Which is what this individual is doing, as he's continually being monitored -- and data collected -- by a team of medical researchers.

You also missed this:

"Some trials showed encouraging signs. For example, older adults treated with low-dose mTOR inhibitors showed stronger immune responses and fewer respiratory infections. Other studies suggested possible improvements in subjective well-being and physical performance, such as walking speed and strength. Still, none of the trials directly showed that rapamycin extends life or clearly slows the aging process.

One small study using a biological aging model (PhenoAge) suggested that users might have reduced their biological age by nearly four years, but the estimate was based on average values, not individual patient data...."

 

[Lounds]

Has he ever considered looking into europeans and asians diet's and actvities that has increased their lifespan. The guy clearly thinks he can beat death. You can't, everything in our universe is born and dies.

If you get to 100 well done you're in the top <1% of people who manage to live a long age but in all honestly who wants to live to the point you can't get out of bed and wipe your own arse?

 

[OortCloud]

A man who takes '54 supplements every day' and gets a gastric issue blames it on the fast food, soda and cereal he ate as a kid. Can he really be that deluded?

 

[MeateaW]

Has he ever considered looking into europeans and asians diet's and actvities that has increased their lifespan. The guy clearly thinks he can beat death. You can't, everything in our universe is born and dies.

If you get to 100 well done you're in the top <1% of people who manage to live a long age but in all honestly who wants to live to the point you can't get out of bed and wipe your own arse?

This is literally his philosophy.

Measure everything he can about his health, change his regimine based on available research, and continually measure everything about his health.

He then publishes his results.

He knows it's an experiment N = 1 and that the value isn't as good as a large scale trial, but he doesn't care. If there is evidence it does good things, he will try it and he will add to the evidence.

Don't get me wrong, he clearly has some kind of mental health issues compelling him to do it. But assuming we can all get over how weird it is, we can stop and look at how he is expressing his weirdness.

Publicly, and transparently. The best way such lunacy can play out.

The alternative is he does all this **** in secret and no one but he himself benefits/is harmed.

As it is, he tests a thing, tells people it doesn't or does work, and continues testing more things.

The fact his mental illness also ensures he sticks rigorously to exercise and diet changes, and ensures he sticks to the treatment plans also ensures the quality of his contribution.

Complete looney, but ... The best kind maybe?

 

[DrSuess]

So, he is simply insane.

Basically.

 

[bennyg]

And instantly he both proves a well known point in our supplement profession - without digestion, absorption is in question, and this variable retrospectively casts into doubt all the data he has generated in his history of personal testing, both internally as the functional impact of his disease progressed, and externally for anyone else interested in replicating his results.

 

[LordVile95]

And instantly he both proves a well known point in our supplement profession - without digestion, absorption is in question, and this variable retrospectively casts into doubt all the data he has generated in his history of personal testing, both internally as the functional impact of his disease progressed, and externally for anyone else interested in replicating his results.

“Biohacking” is nonsense anyway.

Eat a balanced diet that agrees with you, exercise moderately and sleep the correct amount and you’re 99% the way there in most cases.

 

[hk2000]

Why is it the richer they are, the dumber they get?!

 

[bigreddyde]

"No man can redeem the life of another or give to God a ransom for him—the ransom for a life is costly, no payment is ever enough—so that he should live on forever and not see decay."
-- Psalm 49:7-9

Why do you do this?
It has only the slightest of half-assed relevance to the subject. In reality, it's completely off topic.

Stop posting your religious nonsense everywhere. It's obnoxious.

 

[bigreddyde]

"He's also used shock treatments on his genitals in an apparent effort to gain the erections of an 18-year-old."

That... Really does NOT sound right...

 

[Gezzer]

Reminds me of Linus Pauling. While he lived into his 90's he was a staunch advocate for vitamin C megadoses to treat the common cold and prevent cancer. What took him out? Prostate cancer. IMHO it's mostly down to genetics. Knew a lady who smoked about a pack a week since she was a girl in WW2. Diabetic, nearly blind, and mild dementia at 87, but no cancer. She died in the hospital after breaking her hip. Doctors said she could of easily passed 90 if it hadn't happened.

 

[Endymio]

Reminds me of Linus Pauling. While he lived into his 90's he was a staunch advocate for vitamin C megadoses to treat the common cold and prevent cancer. What took him out? Prostate cancer.

In defense of poor old Linus, modern science agrees that vitamin C megadoses do reduce the duration and severity of the common cold, just not the prevalence:

Does vitamin C alleviate the symptoms of the common cold?--a review of current evidence - PubMed

Since 1971, 21 placebo-controlled studies have been made to establish whether vitamin C at a dosage of > or = 1 g/day affects the common cold. These studies have not found any consistent evidence that vitamin C supplementation reduces the incidence of the common cold in the general population. Ne …

pubmed.ncbi.nlm.nih.gov

He was further off base in regards to cancer, but research trials are still ongoing on the use of vitamin C administered intravenously to destroy cancer cells.