Lots of people that are not into IT find the pure Android harder to use than a HTC or Samsung. This is purely based on my experience - they were not fanboys, they just hated that pure interface and also the one on the Motorola Moto G3, Moto E which is similar to one on the Nexus.
I was always chasing the phone with the best camera on the market - that is why I got Note 4 back in its glory days. Now, seeing that Pixel has the best one I am not tempted to buy it, since I hate it's design, it is too expensive , has no card slot. Since they aligned the price close to iPhone, I would also expect the software support to have a life cycle like on iPhone - around 4 years, not around 2 years as it was for the Nexus line.