Not that this news got me excited or anything, but it's good to stay informed, here's a bit to get you started:

Lawmakers and tax officials from more than 30 states are meeting today in Tampa, Fla., to lay the groundwork for taxing digital services sold on the Internet, such as downloadable music, movies and software.

The two-day conference is led by a coalition that last fall approved a plan to make it easier for states to collect sales taxes on products sold over the Internet.

Thinking of online hardware retailers, for example, I believe this could become a large disadvantage as this would add to the cost + the usual shipping we are used to pay when buying online. A medium sized store could become less competitive than larger retailers such as Best Buy, etc.