I second NOD32 and I have been running for 2 years.
Kaspersky is also, very, very good. The best detection rate in the business according to many.
You are going to get a lot of debate in this area. I personally like what they call the layer method, i.e., no security suits but individual choices.
Start with a good router and take it from there.
Anti-Virus: NOD32, Kaspersky, AVG, Avast, AntiVir to name just a few. The latter three all have free versions for the home user. I loaded my daughter's laptop running Vista with Avast free and she hasn't had an issue yet.
Anti-Spyware: SUPERantispyware, AVG; there are others. AVG offers a free version.
Firewalls: Comodo 3.0 (free), Online Armor (they have a very good free version; no Vista release yet), Sunbelt, and ZoneAlarm. OA, Sunbelt, and ZA also offer free versions.