just built a system with this mobo, and the case has 2 usb ports on front that are plugged into a usb header on the mobo, and I have a card reader plugged into another usb header on the mobo as well. this card reader also has one usb port. mobo has 4 usb ports on the back. usb mice and kb, as well as usb network adapter plugged into the mobo, all working. small thumb drives will work in all ports, the hitachi 320GB external wont work in ANY. I tried going through the bios and seeing if I could find something. I also set the jumpers from 5V to 5VSTB figuring it wouldnt change anything and it didnt. I had to use this old rockband powered USB hub for the external and now it works fine. the external even came with a usb cord with 2 male ends to give it additional power if one port wasnt enough. I figured maybe somehow one header didnt have enough power, and after both plugged into the case didnt work, I plugged one into the case and one into the card reader and same problem. the drive just makes a sound similar to what a 1.44 floppy sounds like, like it keeps attempting to spin up and then restarts over and over. I should note this drive doesnt so this on a HP DV6208 laptop or acer aspire one 533 netbook. my sister has this same drive style (250GB though) and had identical problems on her older macbook, but it worked fine on a gateway laptop, my old compaq cq-51 laptop, and their 27" imac... is there anything I can try/do to boost the power to the onboard usb ports? seems kind of rediculous that this new setup cant power a external HDD. when this system boots it loads a screen showing voltages after POST, right before windows starts loading and it shows 4.946v for the 5V spot so I dont think the psu is a problem.