I second that! Even if online active scanning is turned off or it makes you think so. The modules that load into memory use ram and CPU cycles.
For extra coverage use
Virus cleaners that run and exit, and that are redownloaded each time needed.
Use them after a Virus incident from your active online Virus scanner to check with different and sometimes bettter eyes!
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Some powerful Virus cleaners
Nod32
Download
http://finalbuilds.edskes.net/nod32.htm
If the above link if it fails go to
http://home.hccnet.nl/h.edskes/mirror.htm
Slide down near bottom of page find nod32, to the right will be 3 Mirrors marked Online try each one of them will work.
Boot to,Safe mode only to run.
Before Scanning click Setup and click all boxes under Scan typically only System memory is not checked. So check it. Then click logging, Then Scan and clean.
It is very thorough and may detect some other malware cleaners as a threat so if it seems to point say SpyBot then click Leave.
If you have doubt about and issue then Quarintine it and it can be restored.
Depending on CPU and HD speed and the fact we are in (Safe Mode slower also) it could take a while.
Norman Malware remover
http://majorgeeks.com/Norman_Malware_Cleaner__d5450.html
http://majorgeeks.com/Dr.Web_CureIT_d4783.html
http://majorgeeks.com/Kaspersky_Virus_Removal_Tool_d4515.html
http://majorgeeks.com/McAfee_AVERT_Stinger_d4063.html
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There is one Virus scanner that I like that was designed just exactly in answer to your question t
o run with any Virus scanner.
ThreatFire it has been getting better and better.
I have been using ThreatFire for more than a year, it just went from ver 3 to ver 4.
It was designed to be used with and to co-exist with other Virus scanners.
Additionally it uses a totally different process to protect. While conventional Virus scanners work from definitions ThreatFire works on recognizing Virus/Malware activity.
It's like looking at it with 2 sets of eyes and from a different angle.
It works like some Firewalls do to learn what is good/bad.
After install it will ask you about everything that could be a security issue. For example the first time you run IE or FireFox it will prompt you. You would answer to approve and remember the setting. From then on no more prompts about IE or FireFox unless the exe changes like in an update.
As it queries you about the prompt to help you determine to approve or not you can google it with one click.
http://www.threatfire.com/Download/
Mike