Did you install the board chipset drivers as well as graphics driver ?
What graphics card do you actually have? AMD do not make a HD 4880 -the 4800 series are 4830, 4850, 4860, 4870, 4890 and the two dual gpu cards (4850 X2 , 4870 X2)
Other possibilities are that some games are very dependant upon a viable network connection during play, so installing/updating the LAN drivers shouldn't be overlooked. It is also possible that one or more wires into the PCI-E power connector from the power supply is not seated as well as it could be- especially if the cable/PCI-E plug has had to be wrestled in/out of a graphics card power connection.
I assume that you had the same "HD 4880" and power supply in a previous setup and only the motherboard has been changed. Correct?
Was the Asus M2N-SLI board known to be working before you installed it?