Unable to open Task manager

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I have tried many of the possible ways to enable task manager. Used Spy boy and Malwarebytes.
Can you please check the file attached and comment on what should I do?

P.S. I feel once when I was browsing two days back some windows pc defender was getting installed whih the spyware had removed.
Further I am unable to edit the host file.
Unable to upload the host file.
file:///C:/WINDOWS/system32/drivers/etc/hosts

#74.125.45.100 4-open-davinci.com
 
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