From the information you provided, yes the GeForce GTX 980 will work very well with your MSI B85-G41 motherboard. You may want to keep an eye on your PSU though. 500W is the minimum system power requirement (according to the Nvidia website) to run the GeFore GTX 980. If you Overclock the GPU, it may run into some issues with the draw power coming from the PSU, and could cause it to go into an overload.