HELP: Primary master drive fails

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Is there anybody that can help me to figure out this problem? When I start my computer, I read this information after the computer detecting for drivers :"Primary master drive fails". Then, if I start windows (I have win98) under safe mode, everything looks normal. But if I start windows under normal mode, the mouse became idle after two clicks, no mater what I clicked. Also, the keyboard was disabled and I could not do anything. I am not sure what is wrong, the hard drive or the mother board. Thank you for your help.

BTW, I also had this error information "ultra100 bios not installed because no drives attached."
 
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