Cannot open any application

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Weird problem

I can't open up any application, when I log into my PC. Every time I click on any icon on my desktop, the hour glass appears for a couple of seconds, and then disappears, without the program ever opening up (and no, it's not a problem with the shortcut itself).

Sometimes, the only resolution is to restart the PC, and everything seems fine, but then the problem comes back up again.

Any ideas as to why this might be happening would be highly appreciated.
 
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