I am running 2 ea. 34" 4K monitors, I do movie editing, while at times (and sometimes both at the same time) using AutoCad on the other monitor for my engineering work, it will render drawings and moving simulations, while at the same time having a Zoom Video streaming window open showing others the work I do for them. I've never had so much as a flicker (as I knock wood), using an older I9900K intel processor and twin Nvidia 2080Ti cards. I am done buying multiple AMD processors and/or Graphics Cards. Mind you, I am overclocked by 20%.
The chiller I use can cool the processor to 0 degrees if desired, but never need that much, I keep the inside of my case around 34-35 degrees F.