Area 51 was released for the PlayStation 2, Xbox, and Windows platforms, and is a loose remake of the 1995 light gun video game of the same name.

Area 51 at first starts out with intense combat where the player has several AI teammates with him (ranging from two to seven most of the time) versus hordes of mutants. Midway through, the player will have to go through shootouts with more intelligent enemies in the form of alien soldiers. Notable among the voice actors are David Duchovny as Ethan Cole, Marilyn Manson as Edgar the ancient and powerful Grey, Powers Boothe as Major Bridges, and Ian Abercrombie as Dr. Cray.